Giants at Dodgers odds, picks and predictions

The San Francisco Giants (40-29) and the LA Dodgers (41-28) open a 3-game series Friday. First pitch from Dodger Stadium is scheduled for 10:10 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s MLB odds around the Giants vs. Dodgers odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Dodgers won 9-4 last year

The Giants won 2 of 3 games at the Colorado Rockies, failing to complete the sweep with an 8-7 loss as -186 favorites Thursday with the Over (11) cashing. San Francisco had a 97.2% win probability, according to ESPN Analytics, leading 7-2 in the bottom of the fifth Thursday — but was outscored 6-0 in the final 4 innings.

The Dodgers are also coming off a 2-1 series win. They wrapped up their set at the San Diego Padres with a 5-2 victory Wednesday, cashing as -148 favorites with the Under (9.5) hitting. RF Teoscar Hernández hit a tie-breaking 3-run homer in the sixth inning Wednesday, and LF Michael Conforto added a solo shot in the fifth.

Giants at Dodgers projected starters

RHP Logan Webb vs. RHP Yoshinobu Yamamoto

Webb (5-5, 2.58 ERA) makes his 15th start. He has a 1.16 WHIP, 1.8 BB/9 and 10.4 K/9 through 87 1/3 innings.

• Last start: No-decision, 6 IP, 2 ER, 6 H, 0 BB, 10 K in 3-2 home victory over Atlanta Braves Saturday
• 2025 road stats: 2-4, 3.95 ERA (41 IP, 18 ER), 1.24 WHIP, 11.6 K/9 in 7 starts
• 2024 vs. Dodgers: 1-1, 4.57 ERA (21 2/3 IP, 11 ER), 1.62 WHIP, 8.3 K/9 in 4 starts
• Career vs. Dodgers (regular season): 4-6, 4.11 ERA (85 1/3 IP, 39 ER), 1.36 WHIP, 7.5 K/9 in 16 starts

Yamamoto (6-4, 2.20 ERA) makes his 14th start. He has a 1.01 WHIP, 3.1 BB/9 and 10.5 K/9 through 73 2/3 innings.

• Last start: No-decision, 6 IP, 0 ER, 4 H, 2 BB, 9 K in 2-1 setback at St. Louis Cardinals Saturday
• 2025 home stats: 2-2, 2.76 ERA (32 2/3 IP, 10 ER), 1.16 WHIP, 11.3 K/9 in 6 starts
• Career vs. Giants: 1 road start (May 13, 2024), no-decision, 5 2/3 IP, 4 ER, 5 H, 2 BB, 6 K in 6-4 victory in 10 innings

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Giants at Dodgers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:13 a.m. ET.

• Moneyline (ML): Giants +155 (bet $100 to win $155) | Dodgers -190 (bet $190 to win $100)
• Run line (RL)/Against the spread (ATS): Giants +1.5 (-150) | Dodgers -1.5 (+125)
• Over/Under (O/U): 7.5 (O: +100 | U: -120)

Giants at Dodgers picks and predictions

Prediction

Dodgers 4, Giants 3

The Dodgers (-190) are 23-11 at home, while the Giants are 18-18 on the road. LA will likely win Friday, but the price is too high on its ML.

PASS on the ML.

The Giants have covered +1.5 in Webb’s last 2 starts, while the Dodgers have lost straight up in Yamamoto’s last 2 outings — even though he pitched 6 scoreless innings at St. Louis Saturday.

The Giants had their 7-game win streak snapped in Colorado Thursday, but the loss came by just 1 run. San Francisco has not lost by 2 or more runs since May 27 — a stretch of 14 straight games covering +1.5.

BET GIANTS +1.5 (-150).

The Under has cashed in each of Webb’s last 3 starts, and Yamamoto is coming off 6 shutout innings at the Cardinals. However, this hasn’t been a strong spot for Unders this year: The Giants are 14-4 to the Over as road underdogs, and the Dodgers are 20-12 to the Over as home favorites, per TeamRankings.com. With Webb and Yamamoto on the mound, the Under is tempting — but not strong enough for an official play.

LEAN UNDER 7.5 (-125).

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